Post-menopausal women should pay more attention to uterine Sarcoma

Uterine sarcoma is a malignant degree high female genital tumors that originate from the uterine muscle or muscle in connective tissue and endometrial stromal, uterine malignancy 2 ~ 4%.

Good fat in perimenopausal women, multiple age is 50 years old or so. Uterine sarcoma is a rare highly malignant neoplasms of female genital mutilation.

Hazards

Is a rare cancer of the female genital mutilation, representing 1% of malignant tumors of the uterus.

Malignant degree is high, more in women after menopause. If you do not receive treatment, 5-year survival rate of only 20 to 30%.

Uterine Sarcoma can be misdiagnosed as uterine fibroids

Early clinical symptoms uterine Sarcoma multiple non-specific, vaginal bleeding can be a major complaints, accounting for 60% ~ 80%.

Pre-menopausal patients with multiple manifestations of the period, the amount, irregular menstrual bleeding; and postmenopausal patients more performance for the duration of vaginal bleeding after menopause. Secondly, the rapid growth for abdominal mass, vaginal fluid, abdominal pain, abdominal compression symptoms and general discomfort, emaciation, etc.

Uterine Carcinosarcoma preoperative misdiagnosed as uterine fibroids mis-0.2% ~ 0.7%.

Willam reports 332 preoperative considerations for uterine Leiomyoma patients in only 3 cases of uterine Sarcoma (0.23%), which is faster because of myoma growth (1 years of growth greater than 6 weeks) to no uterine Sarcoma occurs. Due to uterine Sarcoma clinical feature is not specific, and the lack of specific tumor markers, so early preoperative diagnosis is difficult. Diagnosis: the diagnosis of uterine Sarcoma scraping is one of the effective means, but there are abnormal bleeding, diagnosis rates only 65.91%.

Literature reports different organization types of uterine Sarcoma patients diagnosed scraping positive rates vary greatly, LMS's scraping the minimum positive rate, ESS and MMT's scraping positive rate is relatively high.

Goff considered the pre-operative consultation scraping ESS missed diagnosis rates, 20% to 40% of LMS, consultation on ESS and MMT scratch-greateropportunities diagnosis, but on uterine Leiomyoma sarcoma of diagnostic value, this and more is located in the uterine muscle lesions or myoma preoperative diagnosis: scraping, within easy access to the lesions. Therefore, consultation scraping negative by cannot except uterine Sarcoma, particularly uterine Leiomyoma.

So on postmenopausal uterine continues to increase, abnormal vaginal bleeding, pain associated with a case under the abdominal distension, taking into account the possibility of uterine Sarcoma, a consultation as possible before shaving.

CT, PET and MRI for the diagnosis of uterine sarcoma. FDG PET can be used for staging preoperative diagnosis, treatment and relapse on residual foci focus monitoring.

Since the general flow within a Sarcoma, color Doppler useful for diagnosis, A in 2010 Kurjak cases nixing hysterectomy patients before a tianxing vaginal color Doppler examination, found all uterine Sarcoma (10 cases) in RI (0.32 ~ 0.42) than the normal uterine myoma and RI small, such as the difference between RI = 0.4 as benign and malignant tumors of the uterus, its sensitivity is 90.91%, specificity of 99.82%, positive predictive value, negative predictive 71.43 99.96%.

But still rely on the pathological confirmed.

Resolution of uterine Leiomyoma and Sarcoma

Many people don't know this myoma and uterine Sarcoma both diseases which is relatively heavy, what's the difference.

These two diseases, one is a benign tumor, malignant neoplasm of an is. The difference between a Word, the result is different.

Uterine sarcomas:

Is a rare highly malignant neoplasms of female genital mutilation.

Uterine Sarcoma accounted for 2% of malignant tumors of the uterus, the issue of age is 50 years old or so. The main clinical manifestations, is vaginal bleeding (postmenopausal bleeding or menstrual abnormalities), abdominal mass (mass to grow quickly, if the growth within the vagina Sarcoma, always interested in mass at prominent vagina. Uterine often grows irregularly, the quality fruit softening), abdominal pain (due to the rapid growth that patients with abdominal pain or pain), the increase in vaginal secretions (serous and bloody or white, merged with infection for Pyogenic, odor), and advanced patients can have weight loss, anemia, fever, systemic failure, pelvic mass infiltration basins, wall, fixed cannot activities.

Before and after the menopause or young irregular vaginal bleeding with uterus increases are to be highly suspect this disease, and further do appropriate checks, especially in the past received radiation therapy, also to be vigilant.

Uterine fibroids:

Is female genital mutilation in the most common benign tumor in the human body, are also common tumors in the 30-year-old-50-year-old women in the higher incidence.

Uterine fibroids are mainly due to the proliferation and formation. Which have a small amount of connective tissue fibers only as a support organization. Its exact name should be a generic term for uterine fibroids, uterine Leiomyoma. Because of its incidence and female hormones (estrogen and progesterone), so the property hormone-dependent cancers.

Uterine fibroid symptoms, in patients with no obvious only in gynecologic examination, or surgery to be found out by accident.

The main symptoms may have menstrual changes (menstrual period is shortened by the amount of increase, or with the extension, and so on, may have irregular bleeding), pain (General, myoma red degeneration occurred or pedunculated myoma torsion and submucous myoma stimulation of spastic contraction occurs, it can cause acute abdominal pain), compression (myoma oppression occurred bladder, urinary frequency, urinary disorders, urinary retention, etc. When can lead to oppression and ureteral hydronephrosis. Uterine myoma can squeeze the posterior wall of the rectum, causing fecal difficulties), increased vaginal discharge, infertility, anemia (long-term volume of menstruation may lead to secondary anemia).

The treatment of uterine Sarcoma go "traditional" line

Uterine Carcinosarcoma only very small malignant tumors of the uterus, representing the female genital tract tumors of 1%.

Because of the relatively rare uterine Sarcoma and histological type is diverse, so is difficult to determine whether therapeutic strategies. Chemotherapy and radiation effects are less than ideal, surgery is the only recognized treatment method, but ovariectomy and lymph node excision of the therapeutic value of surviving controversy.

In 1966-1

989, and 1990-2001, in the same hospital treatment of the 72 cases of uterine Sarcoma patients were included in the study, researchers compare the two periods in patients with lesions of the histological type, staging and treatment of cancer. On the control in patients with pelvic lesions, local or distant metastatic lesions, etc also.

Results showed that patients with a diagnosis of median age 60.5 years.

Common symptoms of reproductive tract bleeding, pelvic pain or abdomen. 34 patients as Leiomyosarcoma (LMT), 25 cases for uterine malignancy in mixed mesodermal (MMT), 12 cases for endometrial stromal sarcomas, 1 case for Angiosarcoma, pathology of type in the two periods of no difference between patients.

Researchers believe the uterine sarcoma is a prognosis of poor little tumor.

Surgery remains the treatment of primary malignant tumors and Metastases of basic methods.

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(Practice editing: xiujie)